The optimal method of providing estradiol to women with POI is by a skin patch or vaginal ring. 10 Estradiol is the natural form of human estrogen. 9 HRT comes in several forms: pills, creams, gels, patches that stick onto the skin, an intrauterine device, or a vaginal ring. Sometimes, the combination might also include testosterone, although this approach is controversial. HRT is usually a combination of an estrogen and a progestin. 1, 5, 6, 7 HRT will not prevent pregnancy, and evidence suggests it might improve pregnancy rates for women with POI by lowering high levels of luteinizing hormone - which stimulates ovulation - to normal in some women.

In addition, HRT is expected to reduce other symptoms, such as hot flashes and night sweats, and help maintain bone health. If a woman with POI begins HRT, she is expected to start having regular periods again. HRT improves sexual health and decreases the risks for cardiovascular disease (including heart attacks, stroke, and high blood pressure) and osteoporosis. It gives the body the estrogen and other hormones that the ovaries are not making.

HRT is the most common treatment for women with POI.

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